About Recurrent IVF Failure

Question : What is Recurrent IVF Failure?
Answer : In females, where endometrium is more than 7 mm and three grade-I embryo transfers (fresh or frozen) turn out with negative results, these are recurrent IVF failure cases. There is no strict guideline by any recognized body to ascertain whether the embryos are grade-I or not, which can confuse clinicians.
Question : How can recurrent IVF failure be prevented?

Answer :

  • 1. Individualized controlled stimulations (administering ovarian stimulation on specific needs of each patient, depending on the pathology)
  • 2. Better selection of the gametes-eggs and sperm by a senior embryologist and advanced techniques like IMSI.
  • 3. Freeze all or freeze more embryo approach.
  • 4. Better selection (8 to 10 mm thickness) as well as optimization (receptivity) of the endometrium (Uterine Lining) during embryo transfer.
Question : Which advanced techniques can tackle recurrent IVF failure cases?
Answer : DNA fragmentation test for a semen analysis is the most important parameter. Using IMSI technology for better sperm selection and time lapse technique for better embryo selection are the technologies for such cases. PGS is an advanced tool to determine the causes of genetic impact on failures, thereby assisting in finding out better genetic qualitative embryo transfer.
Question : Would freezing all embryos be the future approach to treating recurrent IVF failure?
Answer : Better freezing technique by an experienced embryologist will always be better in certain cases, like PCO and poor responder, where freezing all embryos will definitely prevent the IVF failures.